Novel Fate-Tracing Strategies Show that Hepatic Stellate Cells Mediate Fibrosis In Vivo
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چکیده
منابع مشابه
Fate-tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its etiology
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the design of effective antifibrotic therapies. Different cellular sources, including tissue-resident and bone marrow-derived fibroblasts, pericytes and epithelial cells, have been suggested to give rise to myo...
متن کاملHepatic stellate cells and liver fibrosis.
Substantial evidence now exists to recognize hepatic stellate cells (HSCs) as the main matrix-producing cells in the process of liver fibrosis. Liver injury of any etiology will ultimately lead to activation of HSCs, which undergo transdifferentiation to fibrogenic myofibroblast-like cells. Quantitative analysis of HSC activation by immunohistochemistry has been shown to be useful in predicting...
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BACKGROUND We have previously reported that human umbilical cord blood (UCB)-nucleated cells differentiate into hepatocyte-like cells when cultured in a 5-cytokine cocktail medium. We further found that UCB cells rather differentiated into dendritic-shaped cells by coculture with a human stellate cell (HSC) line, LI90. METHODS Monocytes from UCB and adult peripheral blood were cocultured with...
متن کاملOxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells.
AIM To investigate the potential mechanism of Arg-Gly-Asp (RGD) peptide-labeled liposome loading oxymatrine (OM) therapy in CCl₄-induced hepatic fibrosis in rats. METHODS We constructed a rat model of CCl₄-induced hepatic fibrosis and treated the rats with different formulations of OM. To evaluate the antifibrotic effect of OM, we detected levels of alkaline phosphatase, hepatic histopatholog...
متن کاملHepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in development of hepatic fibrosis and there are intricate regulatory effects of...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2014
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2014.04.010